## Background. 4'-O-tetrahydropyranyladriamycin (Pirarubicin, Meiji Seika (USA) Inc., New York, NY) may be less toxic than doxorubicin. A Phase I1 trial of Pirarubicin was done in 26 patients who had not previously had chemotherapy and who had measurable and incurable head and neck carcinoma. All
Activity of pirarubicin (4′-o-tetrahydropyranyladriamycin) in malignant mesothelioma
✍ Scribed by Kasi S. Sridhar; Atif M. Hussein; Lynn G. Feun; C. Gordon Zubrod
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 756 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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Thirty-eight patients with adult acute lymphoblastic leukemia (ALL) or non-Hodgkin's lymphoma (NHL) were treated intravenously with (2"-R)-4'-o-Tetrahydropyranyladriamycin (THP) at a dose of 10 mg/m2 for 5 consecutive days. Seven complete and 15 partial responses were observed in 35 evaluable patien
A phase II study of new anthracycline, THP, was conducted in 46 patients with hematological malignancies in a cooperative study. THP was given intravenously either at a dose of 13-34 mg/m 2 for 3-5 consecutive days or 35-50 mg/m 2 at 3-4 week intervals. Of 21 patients with acute leukemia, complete