Antitumor activity of methotrexate-album
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Andreas Wunder; Gerd Stehle; Hans Herrmann Schrenk; Gernot Hartung; Dieter Ludwi
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Article
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1998
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John Wiley and Sons
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French
โ 159 KB
We have recently reported that albumin accumulates in solid tumors and serves there as a source of nitrogen and energy. Methotrexate-albumin conjugates [MTX( 1)-RSA] derivatized at a molar ratio of 1:1 differ favorably from original MTX in terms of plasma presence and tumor uptake. The purpose of th