✦ LIBER ✦

Activity of alcohol dehydrogenase (adh) isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with breast cancer

✍ Scribed by Wojciech Jelski; Lech Chrostek; Wlodzimierz Markiewicz; Maciej Szmitkowski

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 100 KB
Volume: 20
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.20109

No coin nor oath required. For personal study only.

✦ Synopsis

Numerous experiments have shown that alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) play a significant role in the metabolism of many biological substances. Some metabolic disorders that can lead to breast carcinogenesis may be the cause of changes in ADH and ALDH activity. In previous experiments we found a changed level of class I ADH activity in breast cancer tissues. The changed level of this enzyme in cancer cells may be reflected by the enzyme's activity in the serum. Therefore, in this study we measured the activity of ADH isoenzymes and ALDH in the sera of patients with breast cancer. Serum samples were taken for routine biochemical investigation from 45 women with breast cancer before treatment. Among all tested classes of ADH isoenzymes, only class I had higher activity in the serum of patients with breast cancer in stage IV. The total ADH and ALDH activities were not significantly higher in patients with breast cancer than in healthy controls. The changes in activity, especially in class I ADH, appear to be caused by isoenzymes being released from the organ damaged by metastatic disease.

📜 SIMILAR VOLUMES

Alcohol dehydrogenase (ADH) isoenzymes a

Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer

✍ Wojciech Jelski; Bogdan Zalewski; Maciej Szmitkowski 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

## Abstract The principal enzymes catalyzing the conversion of ethanol to acetate are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The activities of these enzymes are elevated in the serum during the course of alcoholism or cirrhosis. In previous investigations we have found eleva

Gender-related differences in hepatic ac

✍ Lech Chrostek; Wojciech Jelski; Maciej Szmitkowski; Zbigniew Puchalski 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB

## Abstract Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are most abundant in the liver, are the main enzymes involved in ethanol metabolism in humans. Gender‐related differences in total liver ADH and ALDH activity among different animal species have been observed in many s

The activity of class I, II, III, and IV

The activity of class I, II, III, and IV alcohol dehyrogenase isoenzymes and aldehyde dehydrogenase in endometrial cancer

✍ Karolina Orywal; Wojciech Jelski; Michał Zdrodowski; Maciej Szmitkowski 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB

## Abstract __Objective__: The metabolism of cancerous cells is in many ways different than in healthy cells. In endometrial cancer, cells exhibit activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which participate in the metabolism of many biological substances. The aim of

Lactic dehydrogenase isoenzymes in the c

Lactic dehydrogenase isoenzymes in the cerebrospinal fluid of patients with systemic cancer

✍ Martin Fleisher; William R. Wasserstrom; S. Clifford Schold; Morton K. Schwartz; 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 521 KB

Serum enzymes in disease. V. Isocitric d

Serum enzymes in disease. V. Isocitric dehydrogenase, malic dehydrogenase, and glycolytic enzymes in patients with carcinoma of the breast

✍ Arthur Rose; Michael West; Hyman J. Zimmerman 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 English ⚖ 619 KB

Cancer screening of upper aerodigestive

Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase-2 genotype

✍ Akira Yokoyama; Tai Ohmori; Taro Muramatsu; Susumu Higuchi; Tetsuji Yokoyama; Sa 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 458 KB 👁 2 views

In this study, 1,000 Japanese male alcoholics were consecutively screened by upper gastrointestinal endoscopy with esophageal iodine staining. Associations among cancer-detection rates, drinking and smoking habits, and aldehyde dehydrogenase-2 (ALDH2) genotypes were evaluated. A total of 53 patients