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Activity-dependent changes in expression of chondroitin sulfate proteoglycan

โœ Scribed by Shoko Morita; Atsuhiko Oohira; Seiji Miyata

Book ID
116776819
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
81 KB
Volume
65
Category
Article
ISSN
0168-0102

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## Abstract The central nervous system (CNS) fails to regenerate after injury. A glial scar forms at the injury site, contributing to regenerative failure partly resulting from the chondroitin sulfate proteoglycans (CSPGs) in the glial scar. The family of Rho GTPases, which includes Cdc42, Rac1, an

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Chondroitin sulfate (CS) proteoglycans have been implicated as molecules that are involved in axon guidance in the developing neural pathways. The spatiotemporal expression of CS was investigated in the developing retinofugal pathway in mouse embryos by using the CS-56 antibody. Immunoreactive CS wa