The activity and structure-sensitivity of the water-gas shift (WGS) reaction over Cu-Zn-Al mixed oxide catalysts were studied. Three sets of samples with different Cu/Zn and (Cu + Zn)/A1 atomic ratios were prepared by coprecipitation. Depending on the cation ratio, the ternary hydroxycarbonate precursors contained hydrotalcite, aurichalcite and/or rosasite phases. The decomposed precursors contained CuO, ZnO, ZnA120 4, and A1203. The relative proportion of these phases depended on both the chemical composition of the sample and the calcination temperature employed for decomposing the precursor. After activation with hydrogen, samples were tested for the WGS reaction at 503 K. The turnover frequency of the eighteen samples tested was essentially the same (0.2~).3 s -1) irrespective of changing the copper metal surface area between 3 and 35 m~/g Cu and the metallic copper dispersion between 0.5 and 5.0%. This indicated that the WGS reaction is a structure-insensitive reaction, as the specific reaction rate ro (tool CO/h/g Cu) is always proportional to the copper metal surface area. Preparation of mixed oxides with a high copper dispersion is therefore required for obtaining more active catalysts. It was found that the value of the metallic copper dispersion is related to the amount of hydrotalcite contained in the hydroxycarbonate precursor: the higher the hydrotalcite content in the precursor, the higher the copper metal dispersion in the resulting catalyst and, as a consequence, the higher the catalyst activity. Ternary Cu/ZnO/A1203 catalysts exhibited a substantially faster WGS activity than binary Cu/ZnO catalysts. The addition of aluminium, although inactive for the WGS reaction, is required for improving the catalyst performance.