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Activities of MAP-Kinase Pathways in Normal Uroepithelial Cells and Urothelial Carcinoma Cell Lines

✍ Scribed by Sandra Swiatkowski; Hans-Helge Seifert; Christine Steinhoff; Andrea Prior; Ingo Thievessen; Freimut Schliess; Wolfgang A. Schulz


Book ID
115604397
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
325 KB
Volume
282
Category
Article
ISSN
0014-4827

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## Abstract Constitutive activation of hedgehog signaling, often caused by __PTCH1__ inactivation and leading to inappropriate activation of GLI target genes, is crucial for the development of several human tumors including basal cell carcinoma of the skin and medulloblastoma. The __PTCH1__ gene at