## Abstract In 1981, Chugai Pharmaceutical succeeded in marketing alfacalcidol, a prodrug of calcitriol, as a therapeutic agent for renal osteodystrophy. In 1983, Chugai succeeded in extending the application of alfacalcidol to the treatment of osteoporosis as well. Clinicians in Japan have accepte
Active vitamin D and its analogs as drugs for the treatment of osteoporosis: advantages and problems
β Scribed by Yasuho Nishii
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 227 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0914-8779
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Our recent studies have shown that the vitamin D analog Roβ26β9228 restores bone mineral density without inducing hypercalcemia in osteopenic rats. Our ex vivo experiments demonstrated that the analog upregulated gene expression in trabecular bone but not in the duodenum of female rats.
## Abstract Eldecalcitol [1Ξ±,25βdihydroxyβ2Ξ²β(3βhydroxypropyloxy)vitamin D~3~], a vitamin D analog with enhanced efficacy for treatment of osteoporosis, has been found to be less potent than 1,25βdihydroxyvitamin D~3~ (calcitriol) in suppressing PTH in vivo. To define the mechanism for the latter o