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Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial

✍ Scribed by Martin F Muers; Richard J Stephens; Patricia Fisher; Liz Darlison; Christopher MB Higgs; Erica Lowry; Andrew G Nicholson; Mary O'Brien; Michael Peake; Robin Rudd; Michael Snee; Jeremy Steele; David J Girling; Matthew Nankivell; Cheryl Pugh; Mahesh KB Parmar


Book ID
117302962
Publisher
The Lancet
Year
2008
Tongue
English
Weight
231 KB
Volume
371
Category
Article
ISSN
0140-6736

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Cisplatin in combination with irinotecan
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The purpose of this study was to assess the efficacy and toxicity of a combination of cisplatin and irinotecan (CPT-11) in the treatment of patients with malignant pleural mesothelioma and to characterize the pharmacokinetic profiles of CPT-11 and its active metabolite, 7-ethyl-10-hydroxycamptotheci