𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Active specific immunotherapy of guinea pigs with visceral tumor implants

✍ Scribed by Eliyahu Yarkoni; James T. Hunter; Saraswati Sukumar; Herbert J. Rapp

Book ID
104660441
Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
270 KB
Volume
12
Category
Article
ISSN
0340-7004

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✦ Synopsis

Guinea pigs, each with established, 7-day-old, syngeneic visceral micrometastases of line 10 tumor implanted intravenously, were immunized by intradermal inoculations into several sites of a mixture of irradiated line 10 cells and an emulsion containing heat-killed BCG or Mycobacterium phlei bacilli. This treatment led to survival of 72 of 80 treated animals (90%). Therapeutic effectiveness depended on the dose of mycobacteria and on that of irradiated tumor cells. Animals treated by intradermal injection of mycobacteria attached to oil droplets alone or with irradiated tumor cells alone, all died with multiple foci of pulmonary tumor.

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