𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Active site water molecules revealed in the 2.1 Å resolution structure of a site-directed mutant of isocitrate dehydrogenase

✍ Scribed by Diana B Cherbavaz; Myoung E Lee; Robert M Stroud; Daniel E Koshland Jr


Book ID
115629720
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
311 KB
Volume
295
Category
Article
ISSN
0022-2836

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Simultaneous inhibition of anti-coagulat
✍ Nagendra Singh; Ramasamy Prem Kumar; Sanjit Kumar; Sujata Sharma; Rafia Mir; Pun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

## Abstract A novel ligand‐binding site with functional implications has been identified in phospholipase A~2~ (PLA~2~). The binding of non‐steroidal anti‐inflammatory agent indomethacin at this site blocks both catalytic and anti‐coagulant actions of PLA~2~. A group IIA PLA~2~ has been isolated fr

Active-site changes in the pyruvate dehy
✍ Chandrasekhar, Krishnamoorthy ;Arjunan, Palaniappa ;Sax, Martin ;Nemeria, Natali 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 587 KB

The first enzymatic component, E1 (EC 1.2.4.1), of the pyruvate dehydrogenase multienzyme complex (PDHc) utilizes thiamine diphosphate (ThDP) and Mg(2+) as cofactors. The structure of a branched-chain-specific E1 apoenzyme from the heterotetrameric alpha(2)beta(2) E1 family was recently reported and