Synthesis and Aminoacyl-tRNA Synthetase
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Donald Heacock; Craig J. Forsyth; Kiyotaka Shiba; Karin Musier-Forsyth
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Article
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1996
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Elsevier Science
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English
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Two nonhydrolyzable prolyl adenylate analogs, 5ะ-O-[N-(L-prolyl)-sulfamoyl]adenosine (L-PSA) and 5ะ-O-[N-(D-prolyl)-sulfamoyl]adenosine (D-PSA), were prepared in three steps from 2ะ,3ะ-di-O-isopropylideneadenosine. Both of these compounds inhibited the in vitro activity of Escherichia coli and human