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Active Site Models for the Cu A Site of Peptidylglycine α-Hydroxylating Monooxygenase and Dopamine β-Monooxygenase

✍ Scribed by Kunishita, Atsushi; Ertem, Mehmed Z.; Okubo, Yuri; Tano, Tetsuro; Sugimoto, Hideki; Ohkubo, Kei; Fujieda, Nobutaka; Fukuzumi, Shunichi; Cramer, Christopher J.; Itoh, Shinobu


Book ID
120203549
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
746 KB
Volume
51
Category
Article
ISSN
0020-1669

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✍ Emma Langella; Sébastien Pierre; Wadih Ghattas; Michel Giorgi; Marius Réglier; M 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 838 KB

Specific inhibition of the copper-containing peptidylglycine alpha-hydroxylating monooxygenase (PHM), which catalyzes the post-translational modification of peptides involved in carcinogenesis and tumor progression, constitutes a new approach for combating cancer. We carried out a structure-activity