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Active Site Hydration and Water Diffusion in Cytochrome P450Cam: A Highly Dynamic Process

โœ Scribed by Miao, Yinglong; Baudry, Jerome


Book ID
119210010
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
55 KB
Volume
102
Category
Article
ISSN
0006-3495

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Hydration of protein cavities influences protein stability, dynamics, and function. Protein active sites usually contain water molecules that, upon ligand binding, are either displaced into bulk solvent or retained to mediate protein-ligand interactions. The contribution of water molecules to ligand