Active carbonate resins for solid-phase synthesis through the anchoring of a hydroxyl function. Synthesis of cyclic and alcohol peptides

✍ Scribed by Jordi Alsina; Cristina Chiva; Marta Ortiz; Francesc Rabanal; Ernest Giralt; Fernando Albericio

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 302 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02431-8

✦ Synopsis

N,N'-Disuccinimidyl carbonate (DSC) has been successfully used for the efficient conversion of 4-hydroxymethylpolystyrene and 4-hydroxymethyl-3-nitrobenzamido (Nbb) resins into active carbonate resins, which are suitable for the incorporation of molecules via a hydroxyl function. This methodology has been applied to the preparation of the growth hormone inhibitor, Sandostatin.