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Activators of peroxisome proliferator-activated receptor-γ (PPARγ) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells

✍ Scribed by Yoshihisa Kitamura; Jun-ichi Kakimura; Yasuji Matsuoka; Yasuyuki Nomura; Peter J Gebicke-Haerter; Takashi Taniguchi

Book ID
117477446
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
236 KB
Volume
262
Category
Article
ISSN
0304-3940

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## Abstract Reactive astrogliosis is a prominent neuropathologic feature of manganism, a neurodegenerative disorder caused by excessive accumulation of manganese (Mn) in the basal ganglia. Activation of astrocytes has been linked to neuronal injury in manganism resulting from overproduction of infl