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Activation of μ-calpain in developing cortical neurons following methylmercury treatment

✍ Scribed by Jian Zhang; Ken-ichiro Miyamoto; Sadayuki Hashioka; Hai Peng Hao; Koji Murao; Takaomi C. Saido; Hiroshi Nakanishi


Book ID
114134124
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
693 KB
Volume
142
Category
Article
ISSN
0165-3806

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Excessive mu-calpain activation has been linked to several cellular pathologies including excitotoxicity and ischemia. In erythrocytes and other non-central nervous system (CNS) cells, calpain activation is thought to occur following a Ca2+-induced translocation of inactive cytosolic enzyme to membr