Activation of γ-glutamyl transpeptidase in rat liver by toxic doses of dimethylnitrosamine
✍ Scribed by Silvio Fiala; Emerich S. Fiala
- Publisher
- Springer
- Year
- 1971
- Tongue
- English
- Weight
- 122 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0028-1042
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## Abstract To investigate the presence of γ‐glutamyl transpeptidase (γGT) in brain cells, cultures enriched for astroglial cells, neurons, oligodendroglial cells, and microglial cells were studied. Astroglial cultures contained a specific γGT activity of 2.3 ± 0.9 nmol/min/mg protein. A similar sp
γ-Glutamyl transpeptidase is normally not present in adult rat hepatocytes, but its expression is induced by a range of xenobiotics, including carcinogens and chemopreventive agents. Synthesis of the enzyme is mediated by at least six mRNAs transcribed from tandemly arranged promoters on a single ge