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Activation of αvβ3Integrin on Human Osteoclast-like Cells Stimulates Adhesion and Migration in Response to Osteopontin

✍ Scribed by R. Faccio; M. Grano; S. Colucci; A.Zambonin Zallone; V. Quaranta; A.J. Pelletier


Book ID
115582567
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
129 KB
Volume
249
Category
Article
ISSN
0006-291X

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Osteoblast growth and differentiation are critical processes for bone development and maintenance, and are regulated by both humoral and mechanical factors. Humoral (hormonal) factors can affect gene transcription via MAPkinases, e.g., extracellular signal-regulated kinase (ERK). We studied whether