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Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells

✍ Scribed by Naotoshi Sugimoto; Shinji Miwa; Takako Ohno-Shosaku; Hiroyuki Tsuchiya; Yoshiaki Hitomi; Hiroyuki Nakamura; Katsuro Tomita; Akihiro Yachie; Shoichi Koizumi


Book ID
116773156
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
583 KB
Volume
497
Category
Article
ISSN
0304-3940

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In the absence of survival-inducing cytokines activated T cells and neutrophils enter apoptosis spontaneously. Phosphatidylinositol 3-kinase (PI3 K) activation and signaling through PKB/AKT have been widely linked to the inhibition of apoptosis by cytokines. Here we have investigated the role of PKB