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Activation of the Unfolded Protein Response Contributes toward the Antitumor Activity of Vorinostat

✍ Scribed by Kahali, Soumen; Sarcar, Bhaswati; Fang, Bin; Williams, Eli S.; Koomen, John M.; Tofilon, Philip J.; Chinnaiyan, Prakash

Book ID
122228943
Publisher
Neoplasia Press
Year
2010
Tongue
English
Weight
433 KB
Volume
12
Category
Article
ISSN
1522-8002

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## Abstract Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor‐specific conditions, especially glucose deprivation, activate a signaling