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Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytes

✍ Scribed by Andrew J. Lemin; Khalil Saleki; Marcel van Lith; Adam M. Benham

Book ID
118442385
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
455 KB
Volume
581
Category
Article
ISSN
0014-5793

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✍ Matthew J. Turner; Monica L. DeLay; Shuzhen Bai; Erin Klenk; Robert A. Colbert 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 1 views

Objective. HLA-B27 is implicated in the pathogenesis of spondylarthritis (SpA), yet the molecular mechanisms are incompletely defined. HLA-B27 misfolding has been associated with endoplasmic reticulum stress and activation of the unfolded protein response (UPR) in macrophages from HLA-B27/human ␤ 2