Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables
β Scribed by Woo Chul Noh; Yang Hee Kim; Min Suk Kim; Jae Soo Koh; Hyun-Ah Kim; Nan Mo Moon; Nam-Sun Paik
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 237 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Mammalian target of rapamycin (mTOR) pathway positively regulates the cell growth through ribosome biogenesis in many cell type. In general, myostatin is understood to repress skeletal muscle hypertrophy through inhibition of mTOR pathway and myogenesis. However, these relationships hav
A major protective mechanism against oxidizing substances capable of damaging DNA integrity and initiating carcinogenesis is the induction of phase II detoxification and antioxidant enzymes by chemopreventive agents. A key finding in the field of chemoprevention has been the discovery that the induc
## Abstract Breast cancer is a common malignancy with current biological therapies tailored to steroid hormone (ER, PR) and HER2 receptor status. Understanding the biological basis of resistance to current targeted therapies and the identification of new potential therapeutic targets is an ongoing