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Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

✍ Scribed by Watanabe, Hideki; Gaide, Olivier; Pétrilli, Virginie; Martinon, Fabio; Contassot, Emmanuel; Roques, Stéphanie; Kummer, Jean A; Tschopp, Jürg; French, Lars E

Book ID
110049893
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
219 KB
Volume
127
Category
Article
ISSN
0022-202X

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## Abstract Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase‐1 activation and IL‐1β secretion, but the cellular pathways involved remain elusiv