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Activation of the hepatocarcinogen aflatoxin B1 by forms of human hepatic cytochromes P-450: Some do and some don't

✍ Scribed by Herbert L. Bonkovsky

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 408 KB
Volume: 13
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840130533

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✦ Synopsis

Twelve forms of human hepatic cytochrome P-450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P-450's were analyzed for their abilities to activate the potent hepatocarcinogens aflatoxin B1 to metabolites having mutagenic or DNA-binding properties. Five forms,

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