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Activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) is needed for the TGFβ-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells

✍ Scribed by Nestor A. Arita; Daniel Pelaez; Herman S. Cheung


Book ID
116301357
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
355 KB
Volume
405
Category
Article
ISSN
0006-291X

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## Abstract Osteoblasts, the cells responsible for bone formation, derive from mesenchymal stem cells (MSCs) in bone marrow. To acquire a new cell phenotype, uncommitted MSCs must undergo several proliferation and differentiation changes. Although, it is known that extracellular signal‐regulated pr