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Activation of the cAMP/PKA pathway in human mesenchymal stem cells in vitro results in robust bone formation in vivo

✍ Scribed by R. Siddappa; J. Doorn; A. Leusink; C. van Blitterswijk; J. de Boer

Book ID
116320407
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
118 KB
Volume
42
Category
Article
ISSN
8756-3282

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## Abstract Bone grafting is the current standard of care for treatment of fracture nonunions, while alternative strategies such as bone marrow‐derived mesenchymal stem cells are also used. MSCs can be induced towards the osteogenic lineage by in vitro treatment with dexamethasone (dex). This study