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Activation of the c-Ha-ras-1 proto-oncogene by methylation in vitro with α-acetoxy-N-nitrosodimethylamine

✍ Scribed by Samin Hirani-Hojatti; Jamie R. Milligan; Asya Kovnat; Ken Brown; Michael C. Archer

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
709 KB
Volume
2
Category
Article
ISSN
0899-1987

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## Abstract The mutagenicity of oxygen free radicals was studied in a forward mutation system. pEC plasmid containing the human c‐Ha‐__ras__‐1 proto‐oncogene was reacted with oxygen free radicals generated by Cu^2+^ and H~2~O~2~ and was then transfected into NIH/3T3 cells. Transformed foci were obs