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Activation of the c-fos promoter is modulated by PKA in PC12 cells

✍ Scribed by Sugiyama, Takashi; Suzuki, Hirobumi

Book ID
122720370
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
90 KB
Volume
58
Category
Article
ISSN
0168-0102

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Changes in intracellular pH (pHin) take part in the mitogenic response. Their importance has been stressed by the finding that mouse fibroblasts expressing a yeast proton pumping ATPase (PMA?) exhibit a transformed phenotype and are tumorigenic. These cells do maintain a higher pHin, supporting the