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Activation of the Akt/FKHRL1 Pathway Mediates the Antiapoptotic Effects of Erythropoietin in Primary Human Erythroid Progenitors

โœ Scribed by Shahab Uddin; Samanthi Kottegoda; Danielle Stigger; Leonidas C. Platanias; Amittha Wickrema

Book ID
115586347
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
111 KB
Volume
275
Category
Article
ISSN
0006-291X

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## Abstract Guanosine has many trophic effects in the CNS, including the stimulation of neurotrophic factor synthesis and release by astrocytes, which protect neurons against excitotoxic death. Therefore, we questioned whether guanosine protected astrocytes against apoptosis induced by staurosporin