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Activation of Stress-Activated Protein Kinases by Hepatocyte Isolation Induces Gene 33 Expression

✍ Scribed by Claire L. Varley; Suzanne Armitage; Alan J. Dickson


Book ID
115581571
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
119 KB
Volume
254
Category
Article
ISSN
0006-291X

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## Abstract Our study reports that staurosporine induces apoptosis in cultured rat hepatocytes in a dose‐ and time‐dependent fashion. Staurosporine induced apparent cleavage of caspase‐8, caspase‐9, and caspase‐3. The release of cytochrome __c__ from mitochondria, and Bid activation were also detec