Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts

Mechanical force induces type I collagen

Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1

✍ Sung-Ho Kook; Jung-Min Hwang; Jong-Sun Park; Eun-Mi Kim; Jung-Sun Heo; Young-Mi 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB 👁 1 views

## Abstract Type I collagen (COL I) is the predominant collagen in the extracellular matrix of periodontal ligament (PDL), and its expression in PDL fibroblasts (PLF) is sensitive to mechanical force. However, the mechanism by which PLF induces COL I to respond to mechanical force is unclear. This