## Abstract Cholinergic input from the basal forebrain and septum to the hippocampus is well known to be critical in learning and memory. Muscarinic induction of theta‐frequency oscillations may synchronize pre‐ and postsynaptic firing and thereby enhance plasticity in the hippocampus. Previous stu
✦ LIBER ✦
Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses
✍ Scribed by Santschi, Linda A. ;Zhang, Xiao-lei ;Stanton, Patric K.
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 720 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3034
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## Abstract The induction of long‐term potentiation (LTP) of CA3‐CA1 synapses requires activation of postsynaptic __N__‐methyl‐D‐aspartate receptors (GluNRs). At resting potential, the contribution of GluNRs is limited by their voltage‐dependent block by extracellular Mg^2+^. High‐frequency afferen