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Activation of Rac and tyrosine phosphorylation of cytokine receptors induced by cross-linking of integrin α4β1 and cell adhesion in hematopoietic cells

✍ Scribed by Eiichiro Kanda; Zhen-Hua Jin; Daisuke Mizuchi; Ayako Arai; Osamu Miura


Book ID
117053325
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
219 KB
Volume
301
Category
Article
ISSN
0006-291X

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Activation pathways of α4β1 integrin lea
✍ Alfredo Maqueda; José V. Moyano; M. Dolores Gutiérrez-López; Susana Ovalle; José 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 608 KB

## Abstract α4β1 integrin is highly expressed in lymphocytes and is essential in hematopoiesis, extravasation, and the inflammatory response. α4β1 can be activated by intracellular signals elicited upon T‐cell activation by phorbol esters, CD3 crosslinking, or certain chemokine/receptor interaction