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Activation of purinergic P2X receptors inhibits P2Y-mediated Ca2+ influx in human microglia

✍ Scribed by X. Wang; S.U. Kim; C.van Breemen; J.G. McLarnon


Book ID
114483198
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
178 KB
Volume
27
Category
Article
ISSN
0143-4160

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Differential activation of subtype purin
✍ Hyun B. Choi; Seok H. Hong; Jae K. Ryu; Seung U. Kim; James G. McLarnon πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 289 KB

We have studied modulation of purinergic receptors (P(2Y) and P(2X) subtypes) on changes in intracellular Ca(2+) [Ca(2+)](i) and expression and production of COX-2 in human microglia. Measurements using Ca(2+)-sensitive spectrofluorometry showed adenosine triphosphate (ATP) to cause rapid transient