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Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol

✍ Scribed by Roland Seifert; Christoph Schächtele; Günter Schultz


Book ID
115760168
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
569 KB
Volume
149
Category
Article
ISSN
0006-291X

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MARCKS is a widespread cellular phosphoprotein that migrates at \(80-87 \mathrm{kDa}\) on polyacrylamide gels. It is phosphorylated apparently exclusively by protein kinase C (PKC) and its phosphorylation in intact cells can be used as an index of intracellular PKC activation. Most methods for the d