## Abstract Microsomal prostaglandin E synthase‐1 (mPGES‐1) catalyzes the terminal step in the biosynthesis of PGE~2~, which contributes to many physiopathological processes. We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid (BA), and valproic a
✦ LIBER ✦
Activation of peroxisome proliferator-activated receptor γ inhibits IL-1β-induced mPGES-1 expression in human synovial fibroblasts by interfering with Egr-1
✍ Scribed by S Cheng, H Afif, J Martel-Pelletier, J-P Pelletier, X Li, K Farrajota…
- Book ID
- 120707229
- Publisher
- BioMed Central
- Year
- 2004
- Tongue
- English
- Weight
- 391 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar1401
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## Objective: To determine the effects of peroxisome proliferator-activated receptor gamma (ppargamma) agonists on interleukin-1 (il-1) induction of nitric oxide (no) and matrix metalloproteinase 13 (mmp-13) in human chondrocytes. ## Methods: Ppargamma expression and synthesis in human chondrocyt