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Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons

โœ Scribed by Shunsuke Iwano; Norihito Shibahara; Tetsuya Saito; Tetsuya Kamataki


Book ID
116466353
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
135 KB
Volume
580
Category
Article
ISSN
0014-5793

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Polycyclic aromatic hydrocarbon-inducibl
โœ Sudha R. Kondraganti; Pedro Fernandez-Salguero; Frank J. Gonzalez; Kenneth S. Ra ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 264 KB ๐Ÿ‘ 2 views

## Abstract There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens in laboratory animals and are suspected human carcinogens. The PAHs are bioactivated by cytochrome P450 (CYP)1A1/1B1 enzymes to reactive intermediates that bind to DNA, a