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Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia

✍ Scribed by Toshiyuki Mizushima; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Takashi Mashimo; Koichi Noguchi


Book ID
116817401
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
564 KB
Volume
113
Category
Article
ISSN
0304-3959

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## Abstract Cytokine‐induced expression of inducible nitric oxide synthase (iNOS) and concomitant production of nitric oxide (NO) involve activation of mitogen‐activated protein (MAP) kinases and are in most cases mediated by the transcription factor NF‐κB. We investigated the role of p38 MAP kinas