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Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT

✍ Scribed by Ayako Kataoka; Hidetoshi Tozaki-Saitoh; Yui Koga; Makoto Tsuda; Kazuhide Inoue


Book ID
111181187
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
671 KB
Volume
108
Category
Article
ISSN
0022-3042

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Activation of P2X7 receptors induced [3H
✍ Chia-Mei Wang; Yuan-Yi Chang; Jon-Son Kuo; Synthia H. Sun πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 313 KB

ATP is an important signaling molecule in the nervous system and it's signaling is mediated through the metabotropic P2Y and ionotropic P2X receptors. ATP is known to stimulate Ca 2Ο© influx and phospholipase D (PLD) activity in the type-2 astrocyte cell line, RBA-2; in this study, we show that the r