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Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation

✍ Scribed by Joanna A. Pulit-Penaloza; Svetlana V. Scherbik; Margo A. Brinton


Book ID
113948396
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
933 KB
Volume
425
Category
Article
ISSN
0042-6822

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## Abstract Tumor necrosis factor (TNF) is one of the most potent activators of nuclear transcription factor NF‐κB, c‐Jun N‐terminal protein kinase (JNK), and apoptosis in a wide variety of cells. The biological effects of TNF are mediated through sequential interactions of various cytoplasmic prot