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Activation of Nuclear Factor κB by Different Agents : Influence of Culture Conditions in a Cell-Based Assay

✍ Scribed by CHRISTINE E. HELLWEG; ANDREA ARENZ; SUSANNE BOGNER; CLAUDIA SCHMITZ; CHRISTA BAUMSTARK-KHAN

Book ID: 111480716
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 181 KB
Volume: 1091
Category: Article
ISSN: 0890-6564
DOI: 10.1196/annals.1378.066

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## Abstract CHS 828, a pyridyl cyanoguanidine, has been shown to exert a significant antitumor effect in preclinical tests __in vitro__ and __in vivo__, and CHS 828 is in phase I/II clinical trials. We have investigated the effect of CHS 828 on the nuclear factor‐κB (NF‐κB) because of its well‐know