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Activation of N-ras and K-ras induced by interleukin-6 in a myeloma cell line: implications for disease progression and therapeutic response

โœ Scribed by Rowley, Matt; Van Ness, Brian


Book ID
110066583
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
209 KB
Volume
21
Category
Article
ISSN
0950-9232

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Interleukin-6 induces tyrosine phosphory
โœ Carola Neumann; Gundula Zehentmaier; Susanne Danhauser-Riedl; Bertold Emmerich; ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 701 KB

## Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1 Like many other cytokines and growth factors, interleukin-6 (IL-6) activates ~21'"'. However, the precise biochemical mechanisms ind