Inhibition of mTOR signaling by oleanoli
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Rongping Zhou; Zhongmin Zhang; Li Zhao; Chunhong Jia; Song Xu; Qiguang Mai; Ming
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Article
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2011
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Elsevier Science
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English
β 344 KB
## Abstract Oleanolic acid (OA), a pentacyclic triterpenoid exhibits potent antiβtumor activity against many tumor cell lines. But the mechanisms through which OA inhibits osteosarcoma cells are not known. The mammalian target of rapamycin (mTOR) serves as a central regulator of cell growth, prolif