Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells

Amplification of the synovial inflammato

Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor κB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis

✍ Masayoshi Harigai; Masako Hara; Manabu Kawamoto; Yasushi Kawaguchi; Tomoko Sugiu 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB 👁 1 views

## Abstract ## Objective To determine the signal transduction pathways in CD14+ synovial cells from patients with rheumatoid arthritis (RA) after CD40 ligation, and to examine their role in amplifying synovial inflammation in affected joints. ## Methods Expression of messenger RNA was analyzed u