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Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats

✍ Scribed by Nishadi Rajapakse; Katsuyoshi Shimizu; Béla Kis; James Snipes; Zsombor Lacza; David Busija


Book ID
117472839
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
240 KB
Volume
327
Category
Article
ISSN
0304-3940

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✍ C. G. Nichols; E. Niggli; W. J. Lederer 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 355 KB

We have used 'caged-ATP' to investigate the kinetic behavior of KATP channels in ventricular cells from rat heart. In whole cells, loaded with 'caged-ATP', an increase of intracellular [ATP] following a UV light flash produced a decrease of KATP channel current that was too slow (tau approximately 3