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Activation of MEK1, a Raf-1 effector, results in morphologic transdifferentiation in pancreatic carcinoid tumor cells

✍ Scribed by D. Greenblatt; M. Kunnimalaiyaan; H. Chen

Book ID
116702055
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
88 KB
Volume
130
Category
Article
ISSN
0022-4804

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## Abstract Sorafenib is a multikinase inhibitor that has shown promising therapeutic results in different tumor histotypes, both as a single agent or in combination with other treatments. We analyzed the in vitro activity of sorafenib in pancreatic cancer, one of the most lethal and chemo‐radio‐re