Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
โ Scribed by Wu, H.
- Book ID
- 111748270
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 380 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0261-4189
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## Abstract Calcium is a key element in intracellular signaling in skeletal muscle. Changes in intracellular calcium levels are thought to mediate the fastโtoโslow transformation of muscle fiber type. One factor implicated in gene regulation in adult muscle is the nuclear factor of activated Tโcell
## Abstract Calcineurin is constitutively expressed in bone marrowโderived macrophages. However, macrophage response to macrophage colonyโstimulating factor (MโCSF) was not impaired by the use of either calcineurin inhibitors (Wโ13, chlorpromazine and trifluoperazine), calcium chelators (BAPTAโAM)