Point mutations of c-ras genes were investigated in human angiosarcomas of the liver associated with occupational exposure to vinyl chloride. DNA prepared from either frozen or paraffin-embedded tissues was amplified by the polymerase chain reaction, and putative point mutations at codons 12, 13, an
✦ LIBER ✦
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure
✍ Scribed by Marion, M.J.; Froment, O.; Trépo, C.
- Book ID
- 123264148
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 83 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0168-8278
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## Abstract To study the possible role of __ras__ oncogene activation in the dissemination of colon cancer, we determined point mutations in codons 12, 13 and 61 in K‐ and N‐__ras__ in 3 groups of tumors: (A) primary tumors of patients who had undergone surgery for Dukes' B (early‐stage) colon canc