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Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis

✍ Scribed by Shinjiro Kaieda; Chiharu Tomi; Shinji Oki; Takashi Yamamura; Sachiko Miyake


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
827 KB
Volume
56
Category
Article
ISSN
0004-3591

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## Abstract ## Objective OCH, a synthetic analog of α‐galactosylceramide with a truncated sphingosine chain, stimulates natural killer T (NKT) cells to produce predominantly Th2 cytokines. Thus, OCH may be a potential agent for the treatment of Th1‐mediated autoimmune diseases. This study was desi