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Activation of Inhibitory G Protein Catalyzed by GPCR: Molecular Dynamics Simulations of the Activated Cannabinoid CB2 Receptor/Gαi1β1γ2 Protein Complex

✍ Scribed by Singh, Jagjeet; Lynch, Diane; Grossfield, Alan; Leioatts, Nicholas; Pitman, Michael; Reggio, Patricia


Book ID
122227820
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
44 KB
Volume
106
Category
Article
ISSN
0006-3495

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G, and G,, respectively, activate and inhibit the enzyme adenylyl cyclase. Regulation of adenylyl cycldse by the heterotrimeric G, and G, proteins requires the dissociation of GDP and binding of GTP to the a, or a, subunit. The 0-y subunit complex of G, and G, functions, in part, to inhibit GDP diss